Abstract
We reported three cases of ANCA positive refractory otitis media started with otitis media with effusion. All patients initially complained of hearing loss induced by otitis media with effusion, which were not improved by treatments with tympanostomy tube and antibiotics. Serum MPO-ANCAs were detected in all three patients. Two cases were definite in the diagnosis criteria of otitis media with ANCA-associated vasculitis: OMAAV by Harabuchi et al., and one case was ANCA positive otitis media with Polyarteritis nodosa (PAN). In recent years, there has been an increase in reports of patients with OMAAV. The early treatment is needed for good prognosis in terms of hearing preservation. This disease sometimes causes mortal condition, such as subarachnoid hemorrhage. The early diagnosis and early treatment is very important for this disease.
