Otology Japan
Online ISSN : 1884-1457
Print ISSN : 0917-2025
ISSN-L : 0917-2025
The protective effects of IGF1 on the cochlear damage during the insertion of cochlear implant electrodes
Norio YamamotoKohei YamaharaKoji NishimuraHideaki OgitaTakayuki NakagawaJuichi ItoKoichi Omori
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JOURNAL FREE ACCESS

2018 Volume 28 Issue 3 Pages 127-131

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Abstract

In the electric-acoustic stimulation (EAS), hearing preservation, especially in the low-frequency, is the most important issue. To achieve this issue, several methods have been applied including a minimally invasive surgery using soft cochlear implant (CI) electrodes and corticosteroid treatment. However, hearing deterioration after electrode insertion is inevitable on average.

We have been investigating the protective effects of insulin-like growth factor 1 (IGF1) on hair cell death. This effect was observed in the drug- or noise-induced or ischemic hearing loss. Moreover, a local treatment of IGF1 using hydrogel showed positive effects on hearing recovery in our clinical trial on the idiopathic sudden sensorineural hearing loss.

Based on these studies, we assume that IGF1 may be effective on the hearing preservation during CI electrode insertion because of several reasons. 1. One of the causes of hearing impairment after CI electrode insertion is the hair cell loss. 2. Local treatment to the cochlea is easy during CI surgery through cochleostomy or the opening of a round window soon after the impairment. 3. IGF1 is able to prevent hair cell loss. 4. More immediate IGF1 treatment showed better outcomes in our clinical trial. In the current paper, we will present preliminary data on the effects of IGF1 on the cochlear structure during CI electrode insertion.

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© 2018 Japan Otological Society
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