Pathology and Regeneration of Human Middle Ear Mucosa with Otitis Media: Electron Microscopic Study

Abstract

The purpose of this investigation was to observe the morphological change of human middle ear mucosa taken at the middle ear operations for fifteen cases of chronic otitis media or cholesteatoma by electron microscope, and also to determine the possibility and degree of normalization of post-inflammatory middle ear mucosa taken at the second staged operations.
A statement of the conclusions reached as follows;
1. Various stages of inflammatory change were observed in mucosal layer. This variety was also noted in an ear, depending on the location of main pathology.
2. Regeneration of chronically diseased middle ear mucosa was observed in cases that were found to have well aerated and ventilated middle ears after the previousoperations.