Study on the Development of the Air Cell System of Tympanic Bulla in Pigs

Abstract

In the previous repert, it was described that the development of the air cell system of tympanic bulla in pigs was inhibited as a result of the decrease of bone resorption in cortex under the condition of chronic middle ear inflammation. We have further studied about the effect of acute inflammation which was produced by the inoculation with pneumococci in middle ear cleft, following the injection of alycerin, on the development of air cell system and also studied about the effect of antibioties on such the inflammation.
In spite of the use of antibiotics, the produced inflammation was chronic and the inhibition of air cell system appeared later in all cases and the size of tympanic bulla itself reduced in some case. An extent of the inhibition was as same as our previous report, so the effect of the inoculation with pneumococci was not recognized.
The reduction of bone resorption was not recognized at the beginning of inflammation, therefore the inhibition must be induced when the inflammation continued persistently for some long time. And it was thought that the inflammation suppressed not only bone resorption but also bone formation.