Experimental Ménière Attack induced by Injection of the Solutions into the Facial Nerve through the Stylomastoid Foramen

Abstract

Irritative nystagmus directing toward affected side was produced by injection of several solutions such as Ca²⁺ decreasing ajents (Sodium citrate, Na₂-EDTA, NaHCO₃, Na₂C₂O₄) and KCl into the facial nerve through the stylomastoid foramen.
Time course of the nystagmus, the cochlear whole nerve action potential (AP) and cochlear microphonics (CM) were measured in guinea pigs. KCl induced short period of irritative nystagmus and followed to paralytic nystagmus. Ca²⁺ decreasing ajents induced long lasting irritative nystagmus and disappered without paralytic nystagmus. After 3.8% Sodium citrate injection AP and CM amplitudes were decreased and thresholds were elevated.