Abstract
Coenzyme Q (CoQ) has already received a high evaluation in clinical treatment of heart diseases. It has also reported that CoQ is effective for recovery from an acute sudden deafness in our field. However, pharmacokinetics of CoQ in inner ear has not been clarified. The present study focuses on the pharmacokinetics of CoQ using guinea pigs with an acute sensorineural hearing loss which is caused by hypoxic condition. The animals were controlled under the artificial respirater, the blood gas concentration, and the measurements of ABR, ECG, and blood pressure. The ABR gradually went off after the repeated hypoxia. In this occasion, the animals were sacrificed, measured with each of the above tests, and examined the brain and the inner ear by the histological and histochemical methods, SEM and TEM examination.
As the results, CoQ is effective on recovery from the damage of auditory hairs and prevents from the damage of respiratory metabolism of the hair cells which is conducted by the hypoxia.
