Abstract
To investigate the influence of middle ear effusion (MEE) on perilymph (PL), an experimental otitis media with effusion (OME) was manufactured in chinchillas by injecting the tympanic cavity with immune complexes. The mean concentrations of albumin, IgG, histamine and prostaglandin E2 (PGE2) were significantly greater in PLs from OME induced ears than in those from normal control ears. 3H-PGE2 placed on the round window membrane of pathologically affected ears passed into PL in significantly greater amounts than those in normal control. The finidings of the present study indicate that MEE affects biochmical milieu of PL.
