The Effect of Diuretics upon the DC Potential in the Endolymphaticc Sac
1989 Volume 20 Issue 1 Pages 341-342
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1989 Volume 20 Issue 1 Pages 341-342
The effect of furosemide and canrenoate, aldosterone antagonist upon the DC potential in the endolymphatic sac (ESP) was examined in the guinea pig. Furosemide produced no change in the ESP. Canrenoate decreased the ESP, whereas it produced no change in the endocochlear potential (EP). The change in the ESP induced by canrenoate was dose-dependent. The results suggest that the the mechanism underlying the ESP is different from that of the of the EP.
