Role of Type II Collagen in Otosclerosis-like Lesions in Rats

Abstract

In this study, we examined the temporal bone histopathology of Lewis rats immunized with type II collagen under microscope. Moreover, we examined the collagenase production by fibroblasts and macrophages by culturing these cells with spleen cell conditioned medium prepared from rats immunized with type II collagen.
There was no otosclerosis-like lesion in the otic capsule of rats immunized with type II collagen. Collagenase production from fibroblasts and macrophages was high, when these cells were cultured with the spleen cell conditioned medium derived from rats immunized with type II collagen.