Abstract
Our previous paper suggested that secondary immune response in the endolymphatic sac (ES) suppressed caloric response (CR) in the Hartley guinea pigs. In this paper, we analysed the relation between individual course of caloric response and histopathological findings. According to the course of individual CR, we classified it into two groups, the reversible group (n=21) and the nonreversible group (n=9). The reversible group was subdivided into two types, the mild suppressive (MS) type (n=12) and the severe suppressive (SS) type (n=9). Secondary immune response of the ES, seen in most of the animals of the non reversible group and the SS-reversible group, significantly suppressed caloric response within the 1st week after secondary challenge. Vacuolization of the sensory cells of the lateral crista was seen only in the nonreversible group. However there was nocorrelation between the course of CR and the terminal histological findings of endolymphatic hydrops and cellular infiltration of the ES. These results suggest that the course of caloric response following secondary immune response of the ES is greatly dependant on the extent of immune injury to the sensory cells of the lateral crista
