Simulation of Pupil Reaction and Cardiovascular System Model during Cardiopulmonary Resuscitation

Abstract

This paper describes simulation of pupil reaction and cardiovascular system during cardiopulmonary resuscitation (CPR). Traditionally, both pupil diameter and light reflex have been examined to confirm the diagnosis of death. In the present research, qualitative changes in pupil reaction are used for assessing the efficacy of cardiopulmonary resuscitation and as a predictor of outcome. In order to obtain the correlation between pupil diameter and coronary perfusion pressure (CPP), for fifteen domestic male pigs, Zhao et al. measured aortic pressure, pulmonary artery pressure and right atrial pressure through catheter from the femoral artery and vein during cardiopulmonary resuscitation, where ventricular fibrillation was induced with an alternating current delivered to the right ventricular endocardium. By using these data, we made a cardiovascular system model with pupil reaction that predicts to restore spontaneous circulation and cerebral function.