Analysis of Concentration Transport Process with Chemical Reaction for Developing Prediction Methods of Thrombus Formation on Blood Flow

Abstract

To simulate platelet activation and thrombus formation on high shear flows, reaction rate of platelet activation is redefined to be the product of agonists and shear rate factors instead of the original only agonist activation model developed by Sorensen et al. Using this new model, platelet activation is computed on orifice flows with different thresholds of shear rate. The results show that the model is sensitive to the added shear rate factor. It means that distribution of shear rate and concentration transport should be accurately computed because of the model’s sensitivity.