Biocompatibility of the porous film formed on the titanium substrate hydrothermally.

Abstract

Bioactive ceramic coating was formed on titanium substrates hydrothermally CaTiO₃ layers were prepared on the substrates with mixed solution of Cacl₂ and KOH at 150°C and etched by dilute HCl solution at 20-220°C for 24h. When the etching temperature was over 120°C or the pH was lower than 2.6, anatase was formed. These film have high surface area, had 250-300 times larger than that of titanium substrates. HAp deposited on the film with high surface area that anatase formed after soaking in SBF for 7days at 35°C. The amount of deposited HAp, normalizes with the surface area of the film, was almost constant(1.1 μg/cm²), regardless of the surface area of the film.