Abstract
Cytocompatibility of chitosan-organosiloxane hybrids was evaluated due to osteoblastic cell (MG63) adhesion, proliferation and ALP activity. The hybrid showed higher cytocompatibility than chitosan membrane. Biodegradability of the hybrid was also investigated due to reactivity and swelling for phosphate buffer and lysozyme solution. The hybrid showed lower biodegradability than chitosan membrane. Appropriate amount of γ-glycidoxypropyltrimethoxysilane (GPSM) mixed with chitosan affected not only the cytocompatibility but also the biodegradability.
