Biological in vivo evaluation of the apatite-fiber scaffolds which enable 3D-cell culture

Mamoru Aizawa; Hikaru Morisu; Hiroshi Uchida; Takahiko Fujimi; Nobuyuki Kanzawa; Morio Matsumoto; Yoshiaki Toyama

doi:10.14853/pcersj.2004F.0.267.0

17th Fall Meeting of The Ceramic Society of Japan

Session ID : 1L17

DOI https://doi.org/10.14853/pcersj.2004F.0.267.0

Conference information

Host: The Ceramic Society of Japan

Biological in vivo evaluation of the apatite-fiber scaffolds which enable 3D-cell culture

*Mamoru Aizawa, Hikaru Morisu, Hiroshi Uchida, Takahiko Fujimi, Nobuyuki Kanzawa, Morio Matsumoto, Yoshiaki Toyama

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Keywords: Apatite, Biocompatibility, Tissue engineering, Apatite-fiber scaffold, in vivo, Tissue Reaction

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Abstract

Apatite-fiber scaffolds which enable 3D-cell culture have successfully been developed on the basis of processing to control pore sizes of the scaffolds. In vitro/vivo evaluation of the resulting scaffolds were performed using rat-bone morrow cells as a model of osteoblast and animal models. The results clarified that the cells were three dimensionally attached, proliferated, differentiated to culture in a similar environment to human body. When the scaffolds including rh-BMP-2 or rat-bone marrow cell were implanted in subcutaneous tissue of rat/nude mouse, they showed good bone formation.

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