Fabrication of chelate-setting a-tricalcium phosphate cement with bioresorbability and its evaluation

Abstract

We have successfully developed using hydroxyapatite (HAp) particles surface-modified with inositol phosphate (IP6). However, the apatite cement did not have a bioresorbability in the living body. Thus, we developed novel chelate-setting cement with bioresorbability using a-tricalcium phosphate (a-TCP) instead of the HAp as starting materials. The eight kinds of starting a-TCP powders were prepared by ball-milling in the range of 0 to 270 min using a Zr pod and beads. The pure a-TCP cements derived from the ball-milled powder for 120 min attained the highest compressive strength of 18 MPa in the case of the powder/liquid ratio = 1/0.40 [w/w].