Preparation and Material Science Evaluation of β-Tricalcium Phosphate Doped with Vanadate Ions

Abstract

Vanadium is an essential trace element in vivo, and also affects the signaling activation of insulin-like growth factor, which is important factor for bone formation. We have demonstrated that β-tricalcium phosphate (β-TCP) doped with vanadium ions enhanced the bone formation and has low mechanical properties and high solubility. In addition, it was reported that silicate ions replaced the phosphorus sites in β-TCP by co-doping zinc ions. Therefore, we prepared β-TCP doped with vanadate ions. Furthermore, the maximum substitution of vanadate ions and their mechanical properties and in vitro bioabsorbability were investigated.