Cellular response on Na⁺ and Mg²⁺ ions co-doped beta-tricalcium phosphate ceramics

Abstract

Beta-tricalcium phosphate ceramics (b-TCP) is attracting interest as a bioactive artificial implant material because of its chemical affinity, osteoconductivity and connectivity with bone tissue. Na⁺ ions and Mg²⁺ ions have an effect on Ca²⁺ -Na⁺ and Mg²⁺ ATPase of osteoblast. From these facts, Na+ ions and Mg²⁺ ions co-doped b-TCP (Na+Mg-TCP) ceramics were prepared and the cellular behavior was evaluated using osteoblast-like cells. Adhesion of osteoblast-like cells on the b-TCP and Na+Mg-TCP was not different. ALP activity of Na+Mg-TCP was lower than that of b-TCP. In the results, Na + Mg-TCP had ability of bone formation.