Abstract
Hybrids of chitosan and 3-glycidoxypropyltrimethoxysilane (GPTMS) were well osteocompatible. Their hydrogel is suitable as an injectable material for bone-defect repair when they are controllable in viscosity and gelation. Thus, the hydrogels of the chitosan-GPTMS hybrids were prepared using disodium hydrogen phosphate (DSP) or glycerophosphate (GP) to study their gelling and degradation behaviors. As the GPTMS content in the hydrogels and pH of the precursor sols increased, the gelation time decreased, while the hydrogels showed similar profiles of weight loss in the phosphate buffer solution. The hydrogels thus have a potential as injectable materials.
