Preparation and drug releasing properties of novel hemostatic agent containing hydroxyapatite, thermoplastic resin and phosphoryl oligosaccharides of calcium

Abstract

Novel hemostatic agent was prepared using hydroxyapatite (HAp), thermoplastic resin (random copolymer of ethylene oxide and propylene oxide; EPO) and phosphoryl oligosaccharides of calcium (COP); the drug releasing behavior of gentamicin sulfate in the phosphate buffer saline solution was examined by using the hemostatic agents. The starting EPO gel was obtained through the freeze-drying of EPO at -50°C for 15 h and sieving of the freeze-dried materials (sizes: 1 ∼ 2 mm). Also, the nonstoichiometric HAp particles (Ca/P ratio=1.56) were prepared by hydrothermally heating the COP at 100°C for 5 h. The hemostatic agent containing HAp and EPO (HAp/EPO = 0.20) was found to be effective for the inhibition of bleeding and sustained release of gentamicin sulfate.