Preprints of Annual Meeting of The Ceramic Society of Japan
Preprints of Fall Meeting of The Ceramic Society of Japan
Annual Meeting of The Ceramic Society of Japan, 2012
Session ID : 2L06
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In vitro and in vivo evaluation of titanium coated with gelatin and calcium phosphate
TOSHITAKE FURUSAWA, MASAAKI SATO, TOSHIMITSU OKUDERA, KOSUKE MONMA, YUTA MATSUSHIMA, *HIDERO UNUMA
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Keywords: osseointegration, gelatin, calcium phosphate, titanium
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Abstract
The biological efficacy of a double-layer coating of gelatin and calcium phosphate (g/CaP coating) was evaluated by means of MC3T3-E1 culture tests and animal implantation tests. The cell culture tests revealed a considerable extent of calcification on g/CaP coatings while almost no calcification on highly-crystalline HA coatings. When the g/CaP-coated titanium was implanted in the cranial bone defects in GK rats, new bone formation was observed in contact with the implant. On the other hand, the control specimens were surrounded with fibrous tissue. The g/CaP coating promoted bone formation and osseointegration within a short time period even in diabetic rats.
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© The Ceramic Society of Japan 2012
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