Adsorption properties of protein on the Ti surface coated by calcium titanate and effect of protein on pseudo-bone formation

Abstract

Adsorption properties of bovine serum albumin (BSA) and the effect of BSA on pseudo-bone (bone-like apatite) formation in a simulated-body fluid (SBF) on a calcium titanate-coated titanium (CT-Ti) were investigated. CT-coating made the adsorbed amount of BSA decrease, possibly due to lower hydrophobicity of CT-Ti than non-coating Ti. The existence of BSA retarded growth of HAp, which may have been caused by lower degree of over-saturation of calcium ion in SBF owing to binding of calcium ion to the C-terminal of BSA.