Points to Consider for Virus and DNA Removal Processing using Membranes during the Scale-up of Biopharmaceutical Drug Development

Abstract

   Development of biopharmaceutical products can be accelerated by proper selection and application of membranes used during product and process development. This Report will discuss scalability, active product transmission and, filterability focusing on virus removal and DNA removal. Also, it will describe, how proper selection of test filters can eliminate or reduce further testing at pilot and production scales, thus reducing time to submission and marketing of the drug product.