PDA Journal of GMP and Validation in Japan
Online ISSN : 1881-1728
Print ISSN : 1344-4891
ISSN-L : 1344-4891
Articles
Gradient Analysis of Anions and Organic Acids by Using an Ion Chromatography with Eluent Generator
Yoko SEKIGUCHITakahiro SUZUKIKazuo WATANABE
Author information
JOURNAL FREE ACCESS

2003 Volume 5 Issue 2 Pages 96-101

Details
Abstract
  Ion chromatography (IC) is one of the popularly used techniques for determination of inorganic ions in a variety of water analysis market. Recently the target elements include small molecular organic acid. To achieve the simultaneously determination of inorganic ions and organic acids, the gradient elution for ion exchange separation is needed. The gradient elution has brought about various problems. Traditionally, eluents in ion chromatography are prepared off-line from reagent-grade chemicals. However, off-line preparation often introduces contaminants that can cause undesirable chromatographic baseline artifacts and even irreproducible retention times of target analytes during the ion chromatographic separation. Online eluent generation solve most of previous problems. In this paper, the principles of the online eluent generation and applications are described.
Content from these authors
© 2003 Parenteral Drug Association Japan Chapter
Previous article Next article
feedback
Top