A case of Trisomy 8-positive MDS with gastrointestinal lesions that were difficult to differentiate from intestinal BD

Abstract

A 67-year-old man originally suffering from Trisomy 8-positive myelodysplastic syndrome (MDS) and intestinal Bechet's disease (BD) was treated with PSL for symptom control. Symptoms such as hematochezia and abdominal pain did not improve despite increasing the dose of PSL. CT showed wall thickening of the small intestine in the pelvis. Double-balloon endoscopy (DBE) revealed multiple ulcers in the lower ileum with marginal swelling. The patient was started on adalimumab for Trisomy 8-positive MDS gastrointestinal lesions, and although his abdominal pain improved, he died due to massive hematochezia. The number of cases of Trisomy 8-positive MDS gastrointestinal lesions is small, and there are no established methods to differentiate it from inflammatory bowel disease or to treat it. The prognosis of this disease is poor, and more cases need to be accumulated in the future.