2025 Volume 106 Issue 1 Pages 45-47
An 84-year-old woman diagnosed with esophageal small cell carcinoma through endoscopic biopsy was referred to our hospital. Conventional endoscopy revealed a 25 mm 0-IIc lesion with unclear margin on the right wall of lower esophagus, and NBI magnification confirmed Type B1 esophageal cancer as per Japanese classification. Re-biopsy showed small cell carcinoma with 100% Ki67 index. The lesion was diagnosed as esophageal neuroendocrine carcinoma, and magnified endoscopy predicted the invasion depth as cT1a. Considering the age of the patient, the lesion was resected en bloc with ESD. Pathological findings showed a 25 × 18 mm tumor mass with invasion into lamina propria mucosae (LPM), no lymphovascular invasion, and negative horizontal and vertical margin.
The detection of early stage esophageal neuroendocrine carcinoma is extremely rare, and no report has described magnified endoscopic findings so far. We report our findings herein along with a review of literature.
