Abstract
Foveolar hyperplastic polyps are the most popular polyp of the stomach arise from the mucosa of chronic active gastritis. Recent studies suggested hyperplastic polyps arise from inflammatory process of H. pylori gastritis and disappeared or reduced after H. pylori eradication therapy. We report four cases of foveolar hyperplastic polyps of the stomach disappeared and reduced after H. pylori eradication therapy. Including a case of Group IV lesion (adenocarcinoma suspected polyp) disappeared after H. pylori eradication therapy. In all cases, foveolar hyperplastic polyps of the stomach disappeared and reduced after H. pylori eradication therapy. Group IV lesion (adenocarcinoma suspected polyp) also disappeared after H. pylori eradication therapy confirmed by endoscopic mucosal resection. Histological examination of the polyps compared before and after H. pylori eradication therapy revealed foveolar epithlial hyperplasia, inflammatory cell infiltration and stromal edema decreased after H. pylori eradication therapy. Accompany with that, MIB-1 (Ki-67) Labelling index, proliferating cell marker, also decreased markedly. A case of Group IV lesion (adenocarcinoma suspected polyp) disappeared after H. pylori eradication therapy was very rare. It suggested adenocarcinoma arise from hyperplastic polyp confirmed by immunostaining of p53 protein may disappear by H. pylori eradication therapy.
