Abstract
We report two cases of gastrointestinal stromal tumor (GIST) with intramural growth in the stomach.
Patient 1, a 51-year-old woman was studied and showed that upper GI endoscopy revealed a submucosal tumor in the posterior wall of the upper stomach measuring 2cm in diameter. In order to avoid post-operative bleeding, the surgical ligature as the tumor was tied before the electrical resection. Histologically, the tumor was composed of spindle shaped cells with a few mitosis and these cells were negative for S100 and SMA, but strongly positive for CD34 by immunohistochemistry, therefore this tumor correspondanded to GIST, uncommitted type.
Patient 2, a 71-year-old man was admitted to the hospital because of abdominal discomfort. Upper GI series showed a large mass with a delle, which was suspected as a submucosal tumor in the middle body of the stomach. Enhanced CT scan demonstrated that the tumor located in the anterior wall of the stomach and the mass was enhanced homogenously. Distal gastrectomy with adrenectomy was performed because of a suspicion of low grade of malignancy. Immunohistochemical examination revealed that these cells were positive for CD34, c-kit, S100 and SMA, therefore this tumor was diagnosed as GIST, combined type.
