A case of early adenocarcinoma occured after the treatment high grade MALT lymphoma

Abstract

An 83-year-old male was diagnosed as high-grade MALT lymphoma of the stomach both endoscopically and pathologically. Eradication of Helicobacter pylori with 40mg of omeprazole, 1,500mg of amoxicillin, 400mg of clarithromycin a day for 10 consecutive days at first and 3 courses of anthracyline-based chemotherapy (CHOP ; 650mg of cyclophosphamide, 40mg of doxorubicine hydrochloride, 1.2mg of vincristine sulfate per a course and 50mg of predoninn a day during a course) were done secondly and 40Gy of ratiation therapy was added to them. 2 months after whole therapies done, endoscopic examination was performed to evaluated the effect of whole therapies. A type of IIa + IIc, an early gastric adenocarcinoma, was newly revealed to be located on the lesser curvature of the middle body of the stomach. Endoscopic therapy with semiconductor lazer was performed due to the patient's request instead of surgery. The effect of H. pylori infection on the pathogenesis of gastric neoplasia has not been cleared yet. This case suggested the some carcinogen from H. pylori might cause both MALT lymphoma and adenocarcinoma of the stomach.