Abstract
A case infected with Helicobacter pylori (Hp) , which has different sensitivity against amoxicillin (AMPC) , clarithromycin (CAM) and metronidazole (MNZ) according to positions of the stomach, was studied. We performed the susceptibility test by agar plate dilution for Hp in the corpus group, specimen was taken from the greater curvature of the upper corpus, and the corpus-antrum group, specimens were taken from the greater curvature of the upper corpus and the greater curvature of the lower antrum. As a result, 1) There was no case infected with AMPC resistant Hp in both corpus group and corpus-antrum group. 2) The resistance rate for CAM and MNZ was higher in the corpus-antrum group than the corpus group (the corpus-antrum group : 33.3%, the corpus group : 24.2%, respectively) . We found no multidrug resistant Hp. 3) There were different susceptibility for CAM and MNZ between the greater curvature of the lower antrum and the greater curvature of the upper corpus. We found three cases infected with CAM resistant Hp (6.7% out of 45 cases) and two cases infected with MNZ resistant Hp (4.4% out of 45 cases) . 4) These results suggest that the susceptibility test using the biopsy materials taken from the gastric different sites contribute to Hp eradication.
