Abstract
A 47-year-old woman came to our hospital with watery diarrhea and hematochezia. Colonoscopy showed redness and erosions with mucopurulent exudates at the recto-sigmoid junction. The biopsy from the erosion showed neutrophilic and eosinophilic infiltration, crypt abscess and depletion of goblet cells. The serologic testing of anti-Entamoeba histolytica antibodies was negative. The possibility of initial phase ulcerative colitis cannot be ruled out. She was treated with mesalazine. However, mesalazine was ineffective and her general condition deteriorated. Peripferal eosinophillia was noted and second biopsy specimens from the rectum showed massive eosinophilic infiltration leading to a definite diagnosis of eosinophilic colitis. Steriod therapy was administered and her clinical symptoms improved rapidly.
