Abstract
Aim : To clarify the H.pylori eradication ratio between proton-pump inhibitor, ampicillin, metronidazole (PPI/AM : 2nd line) therapy and PPI, ampicillin, clarithromycin (PPI/AC : 1st line) therapy.
Method : Patients with H.pylori infection, who were diagnosed by endoscopic biopsy specimen in community doctor office at Katori City of Chiba prefecture, were included in the study. Patients with gastric and/or duodenal ulcer were received PPI/AC therapy. Patients, who were treated PPI/AC therapy, with failed to eradicate H.pylori were then received PPI/AM therapy. Patients without gastric or duodenal ulcer were received PPI/AM therapy if patients were expected to receive H.pylori eradication therapy. H.pylori eradication ratio between PPI/AM and PPI/AC therapy was compared.
Result : The number of the patients treated with primary therapy of PPI/AC was 77, and 61 out of 77 patients (79.8%) were successful to disinfect. Remaining 14 out of 16 patients with failed to disinfect by primary therapy of PPI/AC were treated with second therapy of PPI/AM, and all patients treated second therapy were successful to disinfect.
The number of the patients treated with primary therapy of PPI/AM was eight, and all patients were successful to disinfect. The analysis of eradication ratio in 1st therapy, PPI/AM (100%；8/8) therapy was higher than PPI/AC (79.8% 61/77) therapy (P＝0.15) . The analysis included 14 patients with received second therapy of PPI/AM, PPI/AM therapy (100%；22/22) was statistically higher than PPI/AC therapy (P＝0.01) . There were no side effects in both treatments.
Conclusion : PPI/AM therapy was higher H.pylori eradication ratio than PPI/AC therapy. All patients received PPI/AM therapy were successful to eradicate H.pylori infection.
