The newly developed MoviPrep can reduce the patients’ burden in the preparation for colonoscopy

Abstract

Background : Colonoscopy is useful and important for early detection of colorectal cancer. There are some elements that can reduce the burden of patients undergoing colonoscopy, including appropriate scope selection, use of appropriate insertion techniques, use of sedation, etc. In 2013, we began to use the next generation-type of bowel cleaning agent, MoviPrep (hypertonic polyethylene glycol : hPEG) .
Aims : The aim of this study was to clarify the significance of using the newly developed hPEG in comparison to the conventional preparation agents.
Methods : We used hPEG for bowel preparation prior to colonoscopy in 120 patients from August to December 2013. Conventionally, we use Niflec (isotonic PEG : iPEG) at our hospital. For this study, we selected 120 iPEG cases, matched for age and sex with cases in which hPEG was used. Patients scheduled to undergo colonoscopy were instructed to take sennoside the night before the procedure, and conventional iPEG or hPEG on the morning of the day of the examination.
We defined preparation time as the duration from the beginning of drinking of the PEG to the time when the nurses confirmed a clear state of the stools. We also defined the duration of drinking and the volume of PEG consumed. Finally, we investigated these parameters in the hPEG group and the iPEG group.
Results : The average age was 63.7 ± 14.0 years in the hPEG group and 64.5 ± 12.8 years in the iPEG group. The preparation time was 144 ± 61 min in the hPEG group and 184 ± 55 minutes in the iPEG group (p< 0.05) . The drinking time was 129 ± 57 min in the hPEG group and 142 ± 37 min in the iPEG group (p< 0.05) . The volume of PEG consumed was 1543 ± 304 ml (hPEG 1033 ml + water 510 ml) in the hPEG group and 1,990 ± 140 ml in the iPEG group (p< 0.05) . There were no complications in either group. The preparation time and volume of PEG consumed were significantly lesser in the hPEG group.
Conclusion : The next-generation MoviPrep is expected as a promising agent to facilitate bowel preparation for colonoscopy, allowing a shorter preparation time, a lower volume of PEG to be consumed, and better drinking quality.