2014 Volume 85 Issue 1 Pages 94-95
A 73-year-old man with a history of gastric ulcer scar underwent chemoradiation therapy for prostate cancer associated with multiple bone and lymph node metastases at the Department of Urology of our hospital. He visited our department because of diarrhea. Laboratory examination revealed a hemoglobin level of 9.6 g/dl, serum alkaline phosphatase level of 4,292 IU/l and serum PSA level of 654.1 ng/ml. The diarrhea improved with the discontinuation of lansoprazole. Upper gastrointestinal endoscopy was performed because of the history of gastric ulcer and history of eradication therapy against Helicobacter pylori infection. Endoscopic examination revealed a reddish protruding lesion measuring about 7 cm in diameter in the greater curvature of the gastric body, with a depression at its top, which was considered likely to be a submucosal tumor. Another similar, but smaller, lesion was also seen near the main lesion. Histological examination of biopsy specimens showed poorly differentiated adenocarcinoma, similar in histology to that of the prostate cancer, which was immunohistologically positive for PSA. Therefore, this case was diagnosed as a case of gastric metastasis from prostate cancer. Thereafter, the patient was admitted with dyspnea associated with bilateral pleural effusion and died four months later. We have reported the rare case of metastasis from prostate cancer to the stomach which was diagnosed by endoscopy.
