Comparison of clinical characteristics of post-eradiation and Helicobacter pylori-positive gastric cancer
2020 Volume 97 Issue 1 Pages 28-32
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2020 Volume 97 Issue 1 Pages 28-32
Purpose: Chronic gastritis caused by persistent Helicobater pylori (HP) infection is the greatest known risk factor for gastric cancer (GC). However, with an increasing number of patients undergoing HP eradication, the incidence of post-eradication cancer is also increasing. The aim of this study is to clarify the characteristics of post-eradication GC.
Methods: This is a single-center retrospective study on all cases of GC that underwent endoscopic submucosal dissection (ESD) at our hospital between 2013 and 2018. Characteristics of post-eradication and HP-positive GC were compared.
Results: Of a total of 1186 cases of GC, 165 (13.9%) were post-eradication GC and 243 (20.5%) were HP-positive GC. Multivariable analysis showed that compared to HP-positive GC, post-eradication GC comprised a higher rate of depressed lesions (67.9 vs 49.4%, p = 0.003), and demonstrated a smaller tumor size (13.4±9.7 vs 17.1±10.4 mm, p = 0.036), and longer operative time (115.0±69.9 vs 110.7±65.3 minutes, p = 0.004). There was no significant difference in resection diameter (37.4±13.0 vs. 40.9±12.5 mm, p = 0.551).
Discussion: Post-eradication GC is detected at a smaller stage than HP-positive GC. The operation time, may have become longer in post-eradication GC due to the difficulty in diagnosing the extent of the lesion.
