Effect of tube feeding on hippocampal-dependent memory in SAMP1 mice

Yoshie Nishida; Mitsuo Iinuma; Yasuo Tamura; Kin-ya Kubo; Fumihiko Iwaku

doi:10.11411/pdj.17.47

Yoshie Nishida, Mitsuo Iinuma, Yasuo Tamura, Kin-ya Kubo, Fumihiko Iwaku

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Keywords: Fos, Hippocampus, SAMP1, Spatial memory, Tube feeding

JOURNAL FREE ACCESS

2007 Volume 17 Issue 1 Pages 47-52

DOI https://doi.org/10.11411/pdj.17.47

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Abstract

This study examined the effect of tube feeding on hippocampal Fos induction and spatial performance in a water maze task in senescence-accelerated mice (SAMP1). Tube feeding accelerated the age-related decline in spatial memory and decreased Fos induction in the hippocampal CA1 region in aged SAMP1 mice. The results suggest that tube feeding in aged SAMP1 mice reduces input activity in the hippocampus, thereby leading to senile memory deficits.

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