Effect of tube feeding on hippocampal-dependent memory in SAMP1 mice

Abstract

This study examined the effect of tube feeding on hippocampal Fos induction and spatial performance in a water maze task in senescence-accelerated mice (SAMP1). Tube feeding accelerated the age-related decline in spatial memory and decreased Fos induction in the hippocampal CA1 region in aged SAMP1 mice. The results suggest that tube feeding in aged SAMP1 mice reduces input activity in the hippocampus, thereby leading to senile memory deficits.