Abstract
We evaluated the effect of dentifrice containing sodium ascorbate on periodontitis. Institutional ethics committee approval was obtained prior to the study. Subjects were 53 patients (15 men and 38 wemen, average age : 44.0 years) with periodontits enrolled in a double-blind clinical trial. We prepared 4 types of dentifrice, i.e., that containing zeolite and sodium monofluorophosphate (D-1), that adding 1.0% sodium ascorbate to D-1 (D-2), that adding 0.1% dl-α-tocopheryl acetate, 0.05% cetylpyridimium chloride, and 0.05% β-glycyrrhetinic acid to D-1 (D-3), and that adding 1.0% sodium ascorbate to D-3 (D-4). Dentifrice was randomly assigned to subjects, who were asked to brush twice daily for 4 weeks. Periodontal indices were measured at baseline, 2-, and 4-week evaluation. As a result for mean bleeding scores of D-2 and D-4, the dentifrices containing sodium ascorbate, a statistically significant difference was seen between baseline and 4-week evaluation (p<0.05, p<0.01). Of the 4 dentifrices, D-4 was the most effective. Statistically significant differences in mean gingival index (p<0.01), probing depth (p<0.01), and bleeding score (p<0.01) were seen between baseline and 4-week evaluation. These results suggest that a dentifrice containing sodium ascorbate is effective against periodontitis.
