2004 Volume 46 Issue 4 Pages 294-305
To determine an effective way for promoting periodontal tissue healing, exposed dental root surfaces in dogs were covered and healing was evaluated histologically and morphologically. Three groups were established : use of atelocollagen and platelet-derived factor (experimental group) ; use of atelocollagen alone (collagen group) ; and use of subepithelial connective tissue graft (control group). Results were as follows : In the experimental group, marked new cementum and bone formation was seen on exposed dental root surfaces and connective-tissue-like adhesion. New cementum and bone formation and connectivetissue-like adhesion increased significantly with time. In the collagen group, coverage of dental root surfaces was less than that in the experimental group, but new cementum and bone formation did occur and connective-tissue-like adhesion was confirmed on exposed dental root surfaces. In the control group, dental root surfaces showed very little new cementum and bone formation, and epithelial invasion was marked and elongated epithelial adhesion seen on exposed dental root surfaces.
The above findings suggest that application of this platelet-derived factor is effective in covering exposed dental root surfaces showing gingival recession.