Abstract
Contents of citric acid, calcium and phosphorus were studied in the serum and bones (maxillary alveolar, mandibular alveolar and femoral bones) of alloxan diabetic rats at 5, 10 and 15 weeks after injection of alloxan. Citric acid was measured by the method of Hori et al, calcium by atomic absorption spectroscopy, and phosphorus by the method of Lowry et al.
The following results were obtained:
1. The citric acid contents in the serum were significantly higher in the alloxan diabetic than the control rats (P<0.05), but the calcium and phosphorus contents were not statistically significant between the alloxan diabetic and the control rats.
2. The citric acid contents in the alloxan diabetic rats were significantly higher at 5 weeks in the maxillary and mandibular alveolar bones and at 5 and 15 weeks in the femoral bones, as compared with those of the control rats (P<0.05).
3. The calcium and phosphorus contents in the maxillary alveolar, mandibular alveolar and femoral bones did not differ from those of the alloxan diabetic and the control rats.
4. Throughout the experimental period, there was no histological difference in the maxillary and mandibular alveolar bone between the alloxan diabetic and the control rats.
