Abstract
The purpose of this investigation was to determine the efficacy of Leftose 30mg tablet (lysozyme chloride preparation) in the management of periodontal disease. 145 adults with gingivitis and/or periodontitis were volunteered in this study.
Leftose was administered systemically to 124 patients for 3 to 42 days (Leftose group), the remaining 21 patients without Leftose were compared as the control (non-Leftose group).
The following clinical measurements were carried out by scoring systems at initial examination and 3 or 7 days after treatment; (a) bleeding, (b) purulent exudation, (e) gingival inflammation, (d) swelling, (e) gingival color, (f) tooth mobility, (g) local pain, (h) halitosis, (i) calculus, (j) plaque and (k) periodontal pocket depth.
No statistically significant differences were found between Leftose group and non-Leftose group at the 0.05 level regarding changes in the clinical measurements. In Leftose group, the effectiveness was more pronounced in the cases of 7-day-administration than those of 3-day-administration. This sug gests that higher dose or longer-term administration would be needed for the treatment of Leftose.
Local theray such as brushing instruction and/or scaling was significantly effective only in the Leftose group in this limitted condition of 7 days observation (p<0.01). It is considered from this result that Leftose potentiated the effect of the local therapy, but further studies will be needed.
