On an Attempt for Juvenile Periodontitis Therapy

Part 1. The Effect of Systemic Administration ofAntibiotics for Juvenile Periodontitis

Abstract

Clinical, bacteriological and immunological findings were evaluated in three individuals with juvenile periodontitis systemically treated with Minomycin (100 mg/day) for 30 days. Gingival crevicular fluid volume, gingival index and pocket depth were reduced in all three patients after Minomycin adminsitration. The percentages of motile rods and spirochetes in the subgingival microflora estimated by phasecontrast microscopic examination were lower than those before treatment. The counts of the subgingival microflora including Haemophilus, Capnocytophaga and black pigmented Bacteroides in selective media were also markedly decreased. Quantities of immunoglobulins (IgG, IgM, IgA) and peripheral blood lymphocyte subsets showed no significant changes after treatment. These results indicate that systemic Minomycin administration may be effective against clinical symptoms and periodontpathic microorganisms withont affecting the immune system.