The Effectiveness of Local Delivery of Ofloxacin Using Controlled-release Strips (PT-01) in Periodontal Patients

Part 1. PT-01 Application among Treatment Plans for Periodontal Disease

Abstract

Three different sites which have more than 5mm pocket were randomly selected in each periodontal patient and were divided into three groups: PT-01 treated site, placebo treated site and control site. After application of either PT-01 or placebo twice for two weeks, subgingval scaling and root planing were performed. Then PT-01 and the placebo were applied weekly to the periodontal pocket for four weeks and clinical and microbiological evaluations were made.
The results obtained were as follows:
1. On clinical evaluation, significant improvement was found in the PT-01 treated site in comparison with the placebo treated and/or control site.
2. On microbiological evaluation, slight improvement was found in the PT-01 treated site, whereas there was no significant difference among the three sites.