Abstract
The present investigation was designed to evaluate periodontal wound healing following implantation with 5 different cross-linked types of atelocollagen membrane. Fourteen mongrel adult dogs were used. After elevating a partial thickness flap following semilunar incision on the buccal aspect of I2, P1, P3, P4, M1 of the maxilla and mandible on the right side, and elevating a full thickness flap at the same sites on the left side, 5 different cross-linked types of atelocollagen membrane were implanted. The dogs were sacrificed to provide observation periods of 1, 3, 5, 7, 14, 21, 28d. after implantation of membranes. Wound healing processes were examined by histopathological observation with regards the timing of membrane absorption and inflammatory reaction.
The results demonstrated that the timing of membrane's absorption was prolonged according to the degree of cross-linking. Among the different crosslinked types of atelocollagen membrane, the degree of inflammatory response with the passage of time was less recognized. In addition, highly cross-linked atelocollagen membranes (Col. . 5, Col. . 10) remained in the body at 28d. after implantation. Especially, the architecture of the tissue infiltrating the remnants of the atelocollagen membranes was different between, in implantation under the partial thickness flap and in implantation under the full thickness flap.
