Abstract
A comprehensive examination was performed on twenty-nine (18 males and 11 females) circulatory disease patients treated with the drugs. The periodontal examination included number of teeth, probing depth (PD), gingival bleeding index (GBI), plaque control record (PCR), gingival index (GI), tooth mobility (TM) and bone index (BI). The patients were divided into the following groups: Ca group (taking calcium antagonists) ; (non-Ca group taking other drugs) ; Hyp group (evidence of gingival hyperplasia) and non-Hyp group (no evidence of gingival hyperplasia).
The mean age of all patients was 55. 44±8.39 range (39-79) years and sixteen patients received calcium antagonists. Nine patients (56.3%) presented gingival hyperplasia and belonged to the Ca group. Furthermore, except one patient, they had all been treated Nifedipine.
The Ca group had significantly deeper PD and less BI than the non-Ca group. The Hyp group had significantly less TM and BI than the non-Hyp group.
The hyperplastic gingiva showed fibrotic and nodular changes, some clefst of the marginal gingiva and various degrees of inflammation.
The gingival biopsies showed slight hyperkeratosis, elongation of the rete pegs, chronic inflammatory infiltration and dense collagen bundles in subepithelial connective tissue.
