Abstract
The present study was performed to evaluate the effect of using P205-Mg0-Si02-CaF-system glass ceramics in combination with a fibrous collagen membrane in guided tissue regeneration (GTR) for periodontal treatment under conditions similar to those of human periodontal disease. After preparing infrabony defects at the approximal surfaces of 19 molar teeth in 2 monkeys, root surfaces were contaminated with plaque for 4 weeks and the experimental sites were assigned into following four groups, Control group: flap operation alone, Group 1: flap operation with implantation of glass ceramic granules, Group 2: guided tissue regeneration using a fibrous collagen membrane, Group 3: implantation of glass ceramic granules in combination with GTR technique using fibrous collagen membrane.
Periodontal condition was observed clinically for 12 weeks.
After twelve weeks, the animals were sacrificed and all the experimental sites were subjected to histopathological observation using non-decalcified preparations.
The follwing results were obtained:
1. In Control Group and Group 1, little newly formed bone and connective tissue attachment was seen.
2. In Group 2, the apical extension of the junctional epithelium was reduced in comparison with group 1 and regeneration of bone and connective tissue attachment was seen.
3. In Group 3, the apical migration of the junctional epithelium was the least of the four groups . Furthermor, the glass ceramic granules had not dropped out. Bone regeneration was seen in a more coronary portion of the footh than in Group 2.
These results suggest that using glass ceramic granules with a fibrous collagen membrane, as part of the GTR technique, employed will provide effective periodontal treatment.
