Abstract
This study evaluated whether periodontal regeneration following reconstructive surgery using Lactide/Glycolide copolymer-atelocollagen complex membrane (LGA) hybridized in vivo may be enhanced or not. Circumferential bone defect models which were produced surgically around mesial roots of the third and fourth premolars in twelve mongrel dogs were used. Three modalities were studied: 1) Control group, in which no membrane was used, 2) LGA group, in which the internal surface of the flap was lined with LGA membrane and 3) HLGA group, in which the internal surface of the flap was lined with LGA membrane hybridized in vivo. After four and twelve weeks of wound healing, the dogs were sacrificed and healing response was analyzed histometrically. The membrane was clearly demonstrated the new cementum formation and the new bone formation were significantly increased in the HLGA group. This result supports that Guided Tissue Regeneration technique using HLGA membrane was one of the methods to promote periodontal tissue regeneration more positively.
