Studies on Clinical and Microbiological Evaluation of Minocycline Hydrochloride with a Local Drug Delivery System in the Acute Phase of Adult Periodontitis

Abstract

The effects of local drug delivery on the acute phase of periodontal disease were clinically and microbiologically studied using a resorbable minocycline-containing strip. The subjects of the study were 43 patients with no systemic disease and no history of antibiotic therapy within three months previously. All 43 patients complained of symptoms such as pain and tenderness from the acute phase area with occasional abscess formation. Minocycline containing strips were gently inserted till they reached the bottom of the pocket. Clinical changes were monitored on 0, 3 and 7 day after insertion of strips, and microbiological changes on 0 and 7 day. Probing depth (PD), pain, tenderness, bleeding on probing (BOP), suppuration (S) and the volume of gingival crevicular fluid (GCF) were recorded. Black Pigmented Gram-Negative Anaerobic Rods (BPNAR) and total anaerobic cultivable counts were made on non-selective blood agar.
Clinical symptoms such as pain, tenderness, BOP and S were significantly reduced on day 3 and 7 compared to the baseline. Significant reduction of PD and GCF were also found on 7 day. The prevalence of BPNAR was significantly decreased on 7 day compared to the baseline.
These results of the present study indicate that the application of resorbable minocycline containing strips to pockets in the acute phase may be effective in improving the acute phase of periodontitis.