Abstract
The purpose of this study was to evaluate the use of cross-linked alginate gel forperiodontal tissue regeneration. Class II furcation was experimentally created in the mandibular premolars of beagle dogs. Periodontal regenerative treatments were then performed with and without topical application of crosslinked alginate gel. A histological evaluation of the effect on new tissue formation, was then performed by comparing periodontal fissure regeneration with and without topical application ofcross-linked alginate gel 2, 4, and 8 weeks after from the flap operations. The following results were obtained:
1. After two weeks, the underdeveloped tissue had enabled the epithelium to intrude into the furcation in the animals that did not receive a topical application of cross-linked alginategel. In the animals that received the application of cross-linked alginate gel, however, the furcation was fully regenerated by new tissue, preventing the epithelium from entering.
2. Throughout the experiment, almost twice as much regenerated cementum was observed in the animals that received the topical application of cross-linked alginate gel compared to those that did not. This difference was statistically significant (p <0. 01). Furthermore, the amount of new regenerated cementum in the second post-operative week was about twice that occurring in the fourth post-operative week. The formation of new cementum in the fourth and eighth post-operative weeks was not significantly different.
3. Regarding the regenerating of new bone, not much of an effect was noticed in either the control or the experimental animals after the second post-operative weeks, but results were observed thereafter. New bone was regenerated in both the cross-linked alginate gel on the regeneration of new bone was statistically significant (p <0. 01).
Consequently, the use of cross-linked alginate gel for the regeneration of periodontal tissue was judged to be beneficial. J. Jpn. Soc. Periodontol., 43: 128-140, 2001.
