2001 Volume 12 Issue 3 Pages 231-237
In 24 patients with deep vein thrombosis treated fibrinolytic and anticoagulant therapy, we evaluated late changes of venous function and recanalization. Recanalization of deep vein thrombosis and venous function were assessed, respectively, by duplex scanning and by Ga-In straingauge plethysmography. In 12 limbs (41%) thrombus was disappeared in the late stage, and venous function became normalized in 5 of the 12 limbs. In the other 7 limbs, despite disappearance of the thrombus, stagnation of venous return remained. Recurrence of deep vein thrombosis was observed in 7 of all the 24 patients, and 5 of all the patients with reccurence had received oral anti-platelet agents. It was suggested that the efficacy of oral administration of anti-platelet agents could not be expected during the period when the possibility of recurrence was high, and that since recurrence occurred before thrombin-antithrombin III complex became normalized, anticoagulant therapy using warfarin was necessary before the complex became normalized.
