Usefulness of Hemostatic Molecular Markers for Diagnosis of Deep Vein Thrombosis

Abstract

Plasma levels of hemostatic molecular markers were significantly high in patients with deep vein thrombosis (DVT), pulmonary embolism (PE), disseminated intravascular coagulation (DIC) and acute myocardial infarction. Especially, activated protein C (APC)-PC inhibitor complex had highest sensitivity and specificity for diagnosis of PE or DVT but APC-α1 antitrypsin complex had high sensitivity for only DIC. PE or DVT was caused by lupus anticoagulant (LA) in 29% of the cases, by PC deficiency in 4%, by malignant tumor in 3%, by antithrombin deficiency in 2%, by DIC in 2%, and by protein S deficiency in 1%. The measurement of hemostatic molecular markers and coagulation tests for LA is necessary for the diagnosis of PE or DVT.